Richard D. Boyce, PhD
Associate Professor of Biomedical Informatics
University of Pittsburgh School of Medicine
Dr. Boyce studies the use of informatics and pharmacoepidemiology to support safe and effective medication therapy, especially for older adults. His research includes developing effective clinical interventions that prevent harm to patients from medication therapy while avoiding known issues with clinical decisions support such as alert fatigue. He also is leading research on how to reduce preventable medication errors related to exposure to drug interactions by helping drug experts more effectively synthesize existing PDDI knowledge, and clinical researchers more rapidly generate evidence to fill in knowledge gaps. He also directs the Informatics Core for the Center of Excellence for Natural Product Drug Interaction Research funded by the National Center Complementary and Integrative Health.
Dr. Boyce has published more than 30 peer reviewed research papers at the intersection of medication safety and informatics. He leads the Pharmacovigilance Evidence Investigation Workgroup in the Observational Health Data Sciences and Informatics consortium (http://goo.gl/5MhTk8) and a W3C Health Care and Life Sciences Interest Group task force that is currently developing a minimum information model for potential drug-drug interactions (https://goo.gl/RHQulO).
Boyce, RD., Voss, E., Huser, V., Evans, L., Reich, C., Duke, JD., Tatonetti, NP., Lorberbaum, T., Dumontier, M., Hauben, M., Wallberg, M., Peng, L., Dempster, S., He, O., Sena, A., Koutkias, V., Natsiavas, P., Ryan, P. LAERTES: An open system architecture for linking pharmacovigilance evidence sources with clinical data. Journal of Biomedical Semantics. Accepted on 1/3/2017. In Process.
E.A. Voss, R.D. Boyce, P.B. Ryan, J. van der Lei, P.R. Rijnbeek, M.J. Schuemie, Accuracy of an Automated Knowledge Base for Identifying Drug Adverse Reactions, Journal of Biomedical Informatics, Available online 16 December 2016, ISSN 1532-0464, http://dx.doi.org/10.1016/j.jbi.2016.12.005.
Samwald M, Xu H, Blagec K, Empey PE, Malone DC, Ahmed SM, Ryan P, Hofer S, Boyce RD. Incidence of Exposure of Patients in the United States to Multiple Drugs for Which Pharmacogenomic Guidelines Are Available. PLoS One. 2016 Oct 20;11(10):e0164972. doi: 10.1371/journal.pone.0164972. PubMed PMID: 27764192. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164972
Boyce RD., Karp JF., Handler SM., Karp, JF., Perera S., Ning, Y., Reynolds III, CF., (2016) “Preparing Nursing Home Data from Multiple Sites for Clinical Research – A Case Study Using Observational Health Data Sciences and Informatics,” eGEMs (Generating Evidence & Methods to improve patient outcomes): Vol. 4: Iss. 1, Article 21. DOI: http://dx.doi.org/10.13063/2327-9214.1252 Available at: http://repository.edm-forum.org/egems/vol4/iss1/21
Boyce RD, Ryan PB, Noren GN, et al. Bridging Islands of Information to Establish an Integrated Knowledge Base of Drugs and Health Outcomes of Interest. Drug Saf. 2014 Jul 2;2:2.
Giménez, JAM., Blagec, K., Boyce, RD., Adlassnig, KP., Samwald, M.. An Ontology-Based, Mobile-Optimized System for Pharmacogenomic Decision Support at the Point-of-Care. PLOS ONE. 2014 May 9(5). DOI: 10.1371/journal.pone.0093769
Boyce RD, Horn JR, Hassanzadeh O, de Waard A, Schneider J, Luciano JS, Rastegar-Mojarad M, Liakata M. Dynamic enhancement of drug product labels to support drug safety, efficacy, and effectiveness. J Bio-med Semantics. 2013 Jan 26;4(1):5. PMID: 23351881. PMCID – PMC3698101.
Boyce R, Collins C, Horn J, Kalet I. Computing with evidence Part I: A drug-mechanism evidence taxonomy oriented toward confidence assignment. J Biomed Inform. 2009; 42 (6):979-89. PMCID: PMC2783801
Boyce R, Collins C, Horn J, Kalet I. Computing with evidence Part II: An evidential approach to predicting metabolic drug-drug interactions. J Biomed Inform. 2009; 42 (6):990-1003. PMCID: PMC2783683.
Handler SM, Boyce RD, Ligons FM, Perera S, Nace DA, Hochheiser H. Use and Perceived Benefits of Mobile Devices by Physicians in Preventing Adverse Drug Events in the Nursing Home. J Am Med Dir Assoc. 2013 Oct 2. doi:pii: S1525-8610(13)00472-6. 10.1016/j.jamda.2013.08.014. Epub 2013 Oct 2. PubMed PMID: 24094901. [PMCID – in process]
Boyce, RD., Freimuth, RR., Romagnoli, KM., Pummer, T., Hochheiser, H., Empey, PE. Toward semantic modeling of pharmacogenomic knowledge for clinical and translational decision support. AMIA Summits Transl Sci Proc. Mar 18 2013:28-32. PubMed PMID: 24303292. PMCID: PMC3814496
Hassanzadeh O, Zhu Q, Freimuth R, Boyce R. Extending the “Web of Drug Identity” with Knowledge Extracted from United States Product Labels. AMIA Summits Transl Sci Proc. 2013 Mar 18;2013:64-68. PubMed PMID: 24303301; PMCID: PMC3814463.
Handler SM, Boyce RD, Ligons FM, Perera S, Nace DA, Hochheiser H. Use and Perceived Benefits of Mobile Devices by Physicians in Preventing Adverse Drug Events in the Nursing Home. J Am Med Dir Assoc. 2013 Oct 2. doi:pii: S1525-8610(13)00472-6. 10.1016/j.jamda.2013.08.014. [Epub ahead of print] PubMed PMID: 24094901. [PMCID – in process]
Boyce RD, Collins C, Clayton M, Kloke J, Horn JR. Inhibitory metabolic drug interactions with newer psychotropic drugs: inclusion in package inserts and influences of concurrence in drug interaction screening software. Ann Pharmacother. 2012;46(10):1287–1298. [PMCID – in process]
Boyce RD, Handler SM, Karp JF, Hanlon JT. Age-related changes in antidepressant pharmacokinetics and potential drug-drug interactions: a comparison of evidence-based literature and package insert information. Am J Geriatr Pharmacother. 2012;10(2):139-50. PMCID: PMC3384538.
Boyce RD, Hanlon JT, Karp JF, Kloke J, Saleh A, Handler SM. A review of the effectiveness of antidepressant medications for depressed nursing home residents. J Am Med Dir Assoc. 2012 May;13(4):326-31. Epub 2011 Oct 21. PubMed PMID: 22019084; PubMed Central PMCID: PMC3340502.
Marshall MS, Boyce R, Deus HF, et al. Emerging practices for mapping and linking life sciences data using RDF — A case series. Web Semantics: Science, Services and Agents on the World Wide Web. 2012;14(0):2–13. [PMCID – in process]
Boyce R, Gardner G, Harkema H. Using Natural Language Processing to Extract Drug-Drug Interaction Information from Package Inserts. In: BioNLP: Proceedings of the 2012 Workshop on Biomedical Natural Language Processing. Montréal, Canada: Association for Computational Linguistics; 2012:206–213. Available at: http://www.aclweb.org/anthology/W12-2426.
Boyce R, Harkema H, Conway M. Leveraging the semantic web and natural language processing to enhance drug-mechanism knowledge in drug product labels. In: Proceedings of the 1st ACM International Health Informatics Symposium. IHI ’10. New York, NY, USA: ACM; 2010:492–496. Available at: http://doi.acm.org/10.1145/1882992.1883070. Accessed March 9, 2012.
