Observational Health Data Sciences and Informatics research

research:all_by_all_incidence

Anonymous (anonymous@undisclosed.example.com) — 2017-12-07T21:01:27+0000

How Often? All-by-all Drug-Condition Incidence Rate Objective: To identify the incidence of clinical conditions/diagnoses following initiation of a given drug. We will systematically calculate incidence rate and incidence proportion for all drugs and all conditions across various times-at-risk and the inclusion/exclusion of patients with incomplete time-at-risk. This analysis will be executed across multiple databases and both summarized numerically and graphically from an aggregate table as w…

research:angioedema

Anonymous (anonymous@undisclosed.example.com) — 2017-12-14T05:54:07+0000

Levetiracetam and Risk of Angioedema in patients with Seizure Disorder Objective: To assess the risk between exposure to Keppra (levetiracetam) and angioedema. Rationale: The Food and Drug Administration (FDA) has recently announced that they are evaluating the need for regulatory action regarding a potential association between exposure to the anti-seizure drug Keppra and angioedema. OHDSI seeks to support evidence generation for questions of importance to FDA and other stakeholders seeking t…

research:bisphosphonates_and_hip_fracture

Anonymous (anonymous@undisclosed.example.com) — 2017-12-14T05:54:57+0000

Comparative effectiveness of alendronate and raloxifene in reducing the risk of hip fracture Objective: To compare the effectiveness in reducing the risk of hip fracture between alendronate and raloxifene. Rationale: Osteoporosis is characterized by decreased bone mass and deterioration of bone tissue, resulting in reduced bone strength and increased fracture risk. Approved therapies for osteoporosis include bisphosphonates, calcitonin, raloxifene and teriparatide. Among these drugs, alendron…

research:cancerstudy

Anonymous (anonymous@undisclosed.example.com) — 2017-09-06T15:04:19+0000

Cancer Treatments Objective: Rationale: Project Lead(s): Coordinating Institution(s): Additional Participants:

research:celecoxib_prediction_models

Anonymous (anonymous@undisclosed.example.com) — 2015-10-17T00:28:05+0000

Predicting outcomes for new users of celecoxib Background Observational data present the opportunity to identify patterns that can be utilized to develop discriminative personalized health outcome risk models. The most widely implemented framework for developing health outcome risk models requires experts to define a set of independent variables, and these are then fed into a logistic or cox regression. The disadvantage of such a framework is that it requires the time consuming aspect of def…

research:celecoxib_vs_nsnsaids

Anonymous (anonymous@undisclosed.example.com) — 2015-10-19T19:55:54+0000

Population-level estimation of comparative risks of Celecoxib versus non-selective NSAIDs Background Observational data is often used to estimate causal effects of prescription drugs on health outcomes. One popular study design that is used for this purpose is the cohort method, where we compare the risk of the outcome of interest in two groups (cohorts) of subjects. Typically the two groups represent two treatment options, where one option could be no treatment. In many ways the cohort metho…

research:celecoxiv_prediction_models

Anonymous (anonymous@undisclosed.example.com) — 2015-10-16T14:54:26+0000

research:characterization_of_oral_antibiotics_for_acne_treatment

Anonymous (anonymous@undisclosed.example.com) — 2020-03-25T15:51:19+0000

Characterization of Oral Antibiotic and Isotretinoin Therapy for Acne Objective: 1. Describe the prevalence of systemic antibiotic treatment for acne by age and gender and to compare how systemic antibiotic prevalence for acne varies by country. 2. Describe the prevalence of systemic isotretinoin treatment for acne by age and gender and to compare how systemic isotretinoin prevalence for acne varies by country. 3. Characterize systemic antibiotic use for acne by type, dose, course duration, nu…

research:comparison_of_combination_treatment_in_hypertension

Anonymous (anonymous@undisclosed.example.com) — 2017-08-07T08:42:36+0000

Comparison of combination treatment in hypertension Objective: The goal of this protocols is conducting comparative effectiveness research to establish evidences for optimal anti-hypertensive combination strategies among patients without cardiovascular outcome from various databases across world.

research:comparison_of_pathologic_bone_fracture_risk_between_between_tenofovir_and_entecavir_in_chronic_hepatitis_b_patients

Anonymous (anonymous@undisclosed.example.com) — 2018-01-24T09:25:24+0000

Comparison of pathologic bone fracture risk between between Tenofovir and Entecavir in chronic hepatitis B patients Objective: To compare the risk of pathologic bone fractures between Tenofovir and Entecavir in chronic hepatitis B patients. Rationale:

research:completed_studies

Anonymous (anonymous@undisclosed.example.com) — 2019-12-02T16:04:56+0000

Completed Studies We currently in the process of consolidating all OHDSI study materials on the OHDSI github and will be retiring this wiki page shortly. Completed studies should be moved here: * Clinical: Treatment Pathways in Chronic Disease * Informatics: Comparison of Achilles Heel outputs * Levetiracetam and Risk of Angioedema in patients with Seizure Disorder * Confidence Interval Calibration Evaluation Study * Comparison of combinati…

research:concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris

Anonymous (anonymous@undisclosed.example.com) — 2020-04-29T21:09:41+0000

Characterization of Oral Antibiotics for Acne Treatment Objective: Aim 1: Characterize the international distribution of oral antibiotic use for acne in the pediatric and young adult population ages 12 to 20. Aim 2: Characterize the international distribution of oral antibiotic use for acne in the adult population ages 21 to 40.

research:confidence_interval_calibration

Anonymous (anonymous@undisclosed.example.com) — 2017-05-03T09:40:49+0000

Confidence Interval Calibration Evaluation Study Objective: This study aims to evaluate confidence interval calibration. Rationale: Observational studies are prone to bias, but unfortunately this bias is often brushed aside with a single comment in the discussion of a paper and is never quantified. In the past we have proposed using negative controls (exposure-outcome pairs where the true relative risk is believed to be one) to produce an empirical bias distribution, and subsequently calibrate…

research:cumcstudy

Anonymous (anonymous@undisclosed.example.com) — 2016-09-09T18:30:13+0000

Quality of Race and Ethnicity Data in the EHR Objective: The purpose of this study is to assess the completeness of data collection for race and ethnicity in the Electronic Health Record of multiple institutions in the US. Rationale: Given the fact that this type of data is used to study health disparities as well as to perform risk assessment for patients, it would be valuable to know the current state of race and ethnicity from a quality perspective.

research:dqstudy

Anonymous (anonymous@undisclosed.example.com) — 2017-11-17T18:32:53+0000

Data Quality Study Objective: The purpose of this study is to assess the data quality using Achilles (especially to test new added rules and to establish data density thresholds for some of the rules. Rationale: Data quality is an important assumption for conducting valid studies.

research:drugs_in_peds

Anonymous (anonymous@undisclosed.example.com) — 2015-11-26T09:13:43+0000

Drug Utilization in Children Background There is a lack of evidence regarding the safety and efficacy of drugs used in children. Most drugs prescribed to children are the same as those originally developed for adults, and are often prescribed simply by extrapolating evidence for adults. Diseases in children, however, might be different from their adult equivalents, and the process underlying growth and development might lead to a different effect or an adverse drug reaction unseen in adults.

research:early_treatment_pathways_for_chronic_conditions

Anonymous (anonymous@undisclosed.example.com) — 2014-12-10T19:46:20+0000

Early Treatment Pathways in Chronic Disease Objective: The objective of this study is to characterize the prevalence of different treatment pathways within the first year of drug initiation for three chronic diseases: Hypertension, Type II Diabetes, and Depression.

research:external_validation_stroke_models

Anonymous (anonymous@undisclosed.example.com) — 2018-05-14T00:43:46+0000

Proof of concept study for externally validating existing stroke models in the OHDSI data network Study: Link to Github Objective: This study aims to demonstrate the power of using the OHDSI network to perform efficient external validation. This will be demonstrated by replicating five well known existing stroke models using the OHDSI patient level prediction framework and then getting the network of researchers to implement the models on their datasets over a 1 month period. The prediction…

research:heelcomparison

Anonymous (anonymous@undisclosed.example.com) — 2016-11-29T17:41:37+0000

PI: Vojtech Huser Details of the study are in the published paper by eGEMS journal Conducted using Achilles v1.1 (version current in 2015); results published in 2016 Huser V, DeFalco F, Schuemie M, Ryan P, Shang N, Velez M, Park RW, Boyce RD, Duke J, Khare R, Utidjian L, Bailey C. Multi-site Evaluation of a Data Quality Tool for Patient-Level Clinical Datasets, eGEMS, 2016 (in press)

research:irb_protocols

Anonymous (anonymous@undisclosed.example.com) — 2019-06-21T15:10:04+0000

Example IRB Protocols Generic CDM-Based Research Protocols for Institutional Review Boards (IRBs) * Generic IRB Proposal * University of Colorado Denver AMC Non-Human Subjects Research OMOP IRB Protocol

research:large-scale_modeling_of_patients_with_thyroid_conditions

Anonymous (anonymous@undisclosed.example.com) — 2017-04-21T19:13:02+0000

Large-scale modeling of patients with thyroid conditions Objective: Characterisation of non-cancerous thyroid disorder population and identification and characterisation of sources of variation within treatment pathways for thyroid conditions. Rationale:

research:largescalepopest

Anonymous (anonymous@undisclosed.example.com) — 2016-09-22T15:11:45+0000

Large-Scale Population-Level Evidence Generation Objective: - Generate evidence for the comparative effectiveness for each pairwise comparison of depression treatments for a set of outcomes of interest.. Rationale: In current practice, most comparative effectiveness questions are answered individually in a study per question. This is problematic because the slow pace at which evidence is generated, but also invites reporting and publishing only those studies where the result is ‘statistically …

research:largescalepred

Anonymous (anonymous@undisclosed.example.com) — 2017-02-02T19:18:36+0000

Proof of concept study for large-scale patient-level predictive modelling in the OHDSI data network Objective: The objective of the large-scale patient-level predictive modelling study is to develop models using 5 commonly used classifiers for a single ‘at risk’ cohort (pharmaceutically treated depression cohort) and 22 ‘outcome’ cohorts. The study is implemented across the OHDSI collaborator network to externally validate the models and assess their transportabilities across the world.…

research:ldl_vs_statin_intensity

Anonymous (anonymous@undisclosed.example.com) — 2014-12-06T21:30:52+0000

LDL Levels vs Statin Intensity as a Predictor of Adverse Cardiac Events Objective: The goal of our study is to evaluate practice-based evidence from to determine whether achieved LDL or statin intensity status is most important in predicting adverse health outcomes.

research:learning_effective_clinical_treatment_pathways_from_data

Anonymous (anonymous@undisclosed.example.com) — 2017-12-02T13:38:43+0000

Learning Effective Clinical Treatment Pathways from Data Objective: Treatment guidelines for the management of type-2 diabetes mellitus (T2DM) are controversial because existing evidence from randomized clinical trials do not address many important clinical questions. An earlier investigation led by Observational Health Data Science (OHDSI) group reveled heterogeneity in the practice of both first and second line treatment choices in T2D with respect to established clinical guidelines. The choi…

research:list_of_sites

Anonymous (anonymous@undisclosed.example.com) — 2015-12-31T14:51:52+0000

Sites with Data in CDM Format A newer list of sites is here: Data below are not perfectly updated. ---------- October 2014 survey identified a list of 58 sites. This wiki list represents a dynamic list of sites (updated by members) Edit the page to add your site (enter size in thousands of patients; eg, 14 000k (=14 million).

research:manuscripts

Anonymous (anonymous@undisclosed.example.com) — 2015-02-12T16:34:25+0000

AMIA 2015 Submissions Please edit page to add any manuscripts in preparation along with a Google Doc link to the work in progress. Due March 12, 2015 * Systems Demonstration: OHDSI Open Source Data Analytics Platform * Add Another Submission Click edit at right to add additional manuscripts's to this list.

research:marc_s_study

Anonymous (anonymous@undisclosed.example.com) — 2017-03-27T18:36:49+0000

Objective: Rationale: Project Lead(s): Coordinating Institution(s): Additional Participants:

research:my_great_study

Anonymous (anonymous@undisclosed.example.com) — 2014-12-02T18:23:21+0000

Objective: Rationale: Project Lead(s): Coordinating Institution(s): Additional Participants:

research:network

Anonymous (anonymous@undisclosed.example.com) — 2014-12-02T05:54:44+0000

OHDSI Research Network The OHDSI Research Network is an international collaboration of researchers seeking to advance observational data research in healthcare. There are currently over 600 million patients with data in the OMOP/OHDSI CDM format. The OHDSI coordinating center is housed at Columbia University and connects with researchers from all over the world.

research:ongoing_studies

Anonymous (anonymous@undisclosed.example.com) — 2019-12-02T16:05:05+0000

Ongoing Studies We currently in the process of consolidating all OHDSI study materials on the OHDSI github and will be retiring this wiki page shortly. If you have study materials on the OHDSI wiki, please move them here: All new studies should be posted is the OHDSI Github Study Protocol Sandbox. Please DO NOT post new study materials on this wiki page.

research:pgx_drug_exposure

Anonymous (anonymous@undisclosed.example.com) — 2017-01-15T00:04:35+0000

Incidence of exposure to drugs for which pre-emptive pharmacogenomic testing is available Objective: Derive data that large healthcare organizations can combine with data on risks of adverse events and cost data to conduct cost-effectiveness / cost-benefit analyses for pre-emptive pharmacogenomics testing

research:project_proposal_template

Anonymous (anonymous@undisclosed.example.com) — 2015-02-16T20:45:51+0000

Incidence of exposure to drugs for which pre-emptive pharmacogenomic testing is available Objective: Derive data that large healthcare organizations can combine data on risks of adverse events and cost data to conduct cost-effectiveness / cost-benefit analyses for pre-emptive pharmacogenomics testing

research:project_proposal_template_2

Anonymous (anonymous@undisclosed.example.com) — 2019-10-17T17:04:44+0000

Investigation of global incidence and outcome of sudden cardiac arrest Objective: To investigate the global trend in the incidence and the outcome of sudden cardiac arrest Rationale: Project Lead(s): Soo Yeon Cho, Seng Chan You, Rae Woong Park

research:project_proposal_template_3

Anonymous (anonymous@undisclosed.example.com) — 2018-05-23T18:54:09+0000

Study Name Objective: Rationale: Project Lead(s): Coordinating Institution(s): Additional Participants: Full Protocol: Initial Proposal Date: Launch Date: Study Closure Date: Results Submission: Requirements CDM: Table Accessed: Database Dialects:

research:protocols_in_development

Anonymous (anonymous@undisclosed.example.com) — 2019-10-17T17:05:19+0000

Protocols under Development We currently in the process of consolidating all OHDSI study materials on the OHDSI github and will be retiring this wiki page shortly. If you have study materials on the OHDSI wiki, please move them here: All new studies should be posted is the OHDSI Github Study Protocol Sandbox. Please DO NOT post new study materials on this wiki page.

research:publications

Anonymous (anonymous@undisclosed.example.com) — 2014-11-11T17:40:17+0000

Publication and Presentations Publications Presentations

research:risk_of_acute_kidney_injury_between_conventional_nsaids_and_selective_cox-2_inhibitors

Anonymous (anonymous@undisclosed.example.com) — 2018-01-10T01:55:55+0000

Risk of acute kidney injury between conventional NSAIDs and selective COX-2 inhibitors Objective: To compare the risk of acute kidney injury between conventional nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 (COX-2) inhibitors.

research:seawas

Anonymous (anonymous@undisclosed.example.com) — 2016-05-19T15:19:09+0000

Investigating Birth Month-Disease Risk Relationships Across the OHDSI Network Objective: Derive data on birth month-disease risk relationships from large healthcare organizations/hospitals and healthcare facilities across the United States of America and throughout the world. Integrative analysis will be performed using established climate models, and knowledge of environmental factors that vary by season and climate.

research:sidebar

Anonymous (anonymous@undisclosed.example.com) — 2015-05-07T20:53:28+0000

Research Studies IRB Protocols

research:studies

Anonymous (anonymous@undisclosed.example.com) — 2018-07-18T16:14:04+0000

OHDSI Research Studies The mission of OHDSI is to generate high-quality evidence through observational research. A primary pathway by which this is accomplished is through collaborative research studies. We currently in the process of consolidating all OHDSI study materials on the OHDSI github and will be retiring this wiki page shortly. If you have study materials on the OHDSI wiki, please move them here:

research:test_charts

Anonymous (anonymous@undisclosed.example.com) — 2016-05-26T07:57:22+0000

WNHR Overview Name Westeros National Health Registry (WNHR) Description The WNHR is a national registry in Westeros. Information from hospitals, pharmacies, and GPs is linked using national person identifiers. This database is a unique source of information on dragon-related injuries

research:themis

Anonymous (anonymous@undisclosed.example.com) — 2017-11-21T19:44:15+0000

Themis Objective: Rationale: Project Lead(s): Themis group Coordinating Institution(s): NIH Additional Participants:

research:treatment_pathways_in_cancer_12mo

Anonymous (anonymous@undisclosed.example.com) — 2017-12-19T20:15:35+0000

Treatment Pathways in Patients with Cancer Objective: Among patients with cancer, characterize the prevalence, variety, and distribution of different initial treatment pathways for three chronic diseases: Hypertension, Type II Diabetes, and Depression. We will systematically summarize the treatment pathways observed among patients who have a diagnosis of cancer and at least

research:treatment_pathways_in_chronic_disease

Anonymous (anonymous@undisclosed.example.com) — 2014-12-06T21:04:20+0000

Treatment Pathways in Chronic Disease Objective: The objective of this study is to characterize the prevalence of different treatment pathways for three chronic diseases: Hypertension, Type II Diabetes, and Depression. We will systematically summarize the treatment pathways observed among patients who have at least 3 years of continuous observation and persistent treatment following initiation. We will stratify the results by year to evaluate temporal trends, and will further stratify by data…

research:treatment_pathways_in_chronic_disease_12_mos

Anonymous (anonymous@undisclosed.example.com) — 2017-12-14T05:55:45+0000

Early Treatment Pathways in Chronic Disease Objective: The objective of this study is to characterize the prevalence of different initial treatment pathways for three chronic diseases: Hypertension, Type II Diabetes, and Depression. We will systematically summarize the treatment pathways observed among patients who have at least

research:treatment_pathways_in_depression

Anonymous (anonymous@undisclosed.example.com) — 2014-12-02T17:58:52+0000

Some comments: 1) I would be interested in using data from our five nursing homes to help with this study but the window of exposure is to long. Our dataset is only 4 years total and so we would have almost no one who meets the inclusion criteria.

research:treatment_pathways_in_hypertension

Anonymous (anonymous@undisclosed.example.com) — 2017-12-14T15:25:57+0000

Treatment Pathways in Hypertension Objective: The objective of this study is to characterize the prevalence of different treatment pathways for patients with hypertension. We will systematically summarize the treatment pathways observed among patients who have at least 3 years of continuous observation and persistent treatment following initiation. We will stratify the results by year to evaluate temporal trends, and will further stratify by data source to determine if treatment pathways vary …