research:concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris
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research:concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris [2016/10/18 17:48] schillil |
research:concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris [2016/11/14 13:03] schillil |
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| - | ====== Oral tetracycline-class Antibiotic Use for Acne Therapy ====== | + | ======Characterization of Oral Antibiotics for Acne Treatment====== |
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| + | **Objective:** // | ||
| + | We aim to characterize 1) the use of oral antibiotics for the treatment of acne in children and adolescents and 2)assess guideline compliance of current clinical practice around the world.// | ||
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| + | **Rationale:** //Acne is a common and disabling medical problem, especially among adolescents.[1] Guidelines established by the American Academy of Dermatology (AAD) recommend to minimize the duration of systemic antibiotics for the management of acne ideally to 3-4 months and no longer than 6 months in order to decrease risk of resistance.[1] A recent systematic review demonstrated that over 50% of P acnes strains are reported as resistant in all major regions of the world.[2] In addition to promoting resistance, long-term oral antibiotic use has been associated with a number of adverse events including microbiome disruption and pharyngitis, and possible associations with inflammatory bowel disease and obesity.[3] Despite these adverse effects, oral antibiotics are often prescribed for acne for longer durations than acne guidelines recommend.[3] A large retrospective cohort study of teenagers in the UK revealed that 29% of antibiotic courses prescribed by general practitioners exceeded 6 months in duration.[3] OHDSI network evidence will identify areas of the globe most in need of improving guideline concordance.// | ||
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| + | **Project Lead(s):** //Stephanie Chapman, Renee Domozych, Jessica Mounessa, Jonathan Silverberg, David Barbieri, Robert P. Dellavalle, Lisa M. Schilling// | ||
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| + | **Full Draft Protocol:** {{research:acne:acne_abx_characterization_protocol.docx}} | ||
| - | **Objective:** //The objective of this study is to 1) characterize the use of tetracycline-class antibiotics for the treatment of acne in children and adolescents and 2) expand upon a recent study to more fully describe acne oral tetracycline-class antibiotic use around the world // | ||
| - | **Rationale:** //Acne is a common and disabling medical problem, especially among adolescents. The American Academy of Dermatology (AAD) has published guidelines for the use of systemic antibiotics for the management of acne. These include: 1) minimizing the duration of therapy (ideally to 3-4 months and no longer than 6 months) to decrease risk of resistance and 2) prescribing concomitant treatment with a topical retinoid or topical retinoid/benzoyl peroxide to increase efficacy. In addition to promoting resistance, long-term oral antibiotic use has been associated with a number of adverse events including microbiome disruption and pharyngitis, and potentially inflammatory bowel disease and obesity. Yet oral antibiotics are often over-prescribed. A large retrospective cohort study of teenagers in the UK revealed that of antibiotic courses prescribed by general practitioners, 29% exceeded 6 months in duration, and 62% were not associated with a topical retinoid. Our study aims to describe the type and duration of oral tetracycline-class antibiotic therapy for the treatment of acne around the world. The evidence through the OHDSI network may help identify a need to improve concordance to achieve the best treatment efficacy for patients.// | ||
| - | **Project Lead(s):** //Stephanie Chapman, Renee Domozych, Jessica Mounessa, Jonathan Silverberg, David Barbieri, David Margolis, Robert P. Dellavalle, Lisa Schilling// | ||
| - | **Full protocol:** {{:research:acne_vulgaris_full_study_protocol.docx|Acne vulgaris treatment study protocol}} | ||
| - | Please provide any comments or suggestions. | + | //Please provide any comments or suggestions.// |
| ===== Forum Discussion Thread ===== | ===== Forum Discussion Thread ===== | ||
| [[http://forums.ohdsi.org/t/ohdsi-study-concordance-with-antibiotic-treatment-guidelines-for-acne/1703]]// | [[http://forums.ohdsi.org/t/ohdsi-study-concordance-with-antibiotic-treatment-guidelines-for-acne/1703]]// | ||
research/concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris.txt · Last modified: 2020/04/29 21:09 by crundle
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