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--- research:concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris [2016/09/30 21:26]
schillil [Concordance with AAD guidelines for the treatment of acne vulgaris]
+++ research:concordance_with_aad_guidelines_for_the_treatment_of_acne_vulgaris [2016/11/14 13:03]
schillil
@@ Line 1: / Line 1: @@
-====== Concordance with AAD guidelines for the treatment of acne vulgaris======
+ ======Characterization of Oral Antibiotics for Acne Treatment======
+**Objective:** //
+We aim to characterize 1) the use of oral antibiotics for the treatment of acne in children and adolescents and 2)assess guideline compliance of current clinical practice around the world.//
+**Rationale:** //Acne is a common and disabling medical problem, especially among adolescents.[1] Guidelines established by the American Academy of Dermatology (AAD) recommend to minimize the duration of systemic antibiotics for the management of acne ideally to 3-4 months and no longer than 6 months in order to decrease risk of resistance.[1] A recent systematic review demonstrated that over 50% of P acnes strains are reported as resistant in all major regions of the world.[2] In addition to promoting resistance, long-term oral antibiotic use has been associated with a number of adverse events including microbiome disruption and pharyngitis, and possible associations with inflammatory bowel disease and obesity.[3] Despite these adverse effects, oral antibiotics are often prescribed for acne for longer durations than acne guidelines recommend.[3] A large retrospective cohort study of teenagers in the UK revealed that 29% of antibiotic courses prescribed by general practitioners exceeded 6 months in duration.[3] OHDSI network evidence will identify areas of the globe most in need of improving guideline concordance.//
+**Project Lead(s):** //Stephanie Chapman, Renee Domozych, Jessica Mounessa, Jonathan Silverberg, David Barbieri, Robert P. Dellavalle, Lisa M. Schilling//
+**Full Draft Protocol:** {{research:acne:acne_abx_characterization_protocol.docx}}
-**Objective:** //The objective of this study is to evaluate physician concordance with AAD guidelines for the treatment of acne vulgaris.//
-**Rationale:** //The American Academy of Dermatology (AAD) has published guidelines for the use of systemic antibiotics for the management of acne. These include: 1) minimizing the duration of therapy (ideally to 3-4 months and no longer than 6 months) to decrease risk of resistance and 2) prescribing concomitant treatment with a topical retinoid or topical retinoid/benzoyl peroxide to increase efficacy. A large retrospective cohort study of teenagers in the United Kingdom revealed that of antibiotic courses prescribed by general practitioners, 29% exceeded 6 months in duration, and 62% were not associated with a topical retinoid. Our study aims to determine adherence with AAD guidelines for oral antibiotic use in the management of patients with acne among general practitioners and dermatologists in the United States and other countries. The evidence through the OHDSI network may help identify a need to improve concordance to achieve the best treatment efficacy for patients.//
-**Project Lead(s):** //Stephanie Chapman, Renee Domozych, Jessica Mounessa, Robert P. Dellavalle, Lisa Schilling//
-**Full protocol:** {{:research:acne_vulgaris_full_study_protocol.docx|Acne vulgaris treatment study protocol}}
-Please provide any comments or suggestions.
+//Please provide any comments or suggestions.//
 ===== Forum Discussion Thread =====
 [[http://forums.ohdsi.org/t/ohdsi-study-concordance-with-antibiotic-treatment-guidelines-for-acne/1703]]//

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