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Transfusions are special treatments which are currently in active research by the FDA BEST and the [[https://www.nhlbi.nih.gov/science/recipient-epidemiology-and-donor-evaluation-study-reds-program|REDS-IV]] program. The current OMOP CDM allows only partial capture of relevant transfusion information to support the various research use cases (see below). This Working Group intends to close that gap. | Transfusions are special treatments which are currently in active research by the FDA BEST and the [[https://www.nhlbi.nih.gov/science/recipient-epidemiology-and-donor-evaluation-study-reds-program|REDS-IV]] program. The current OMOP CDM allows only partial capture of relevant transfusion information to support the various research use cases (see below). This Working Group intends to close that gap. | ||
- | * [[documentation:transfusion:Data_Source|Use Cases]] | + | == Use Cases == |
+ | |||
+ | * Effect of number of units on outcomes | ||
+ | * Effect of single donor vs pooled on outcomes | ||
+ | * Effect agency blood products are obtained from (such as ARC vs NYBC) on outcomes | ||
+ | * Incidence rates of severe outcomes: TRALI, TACO, Sepsis, HTRs, PTP, thrombosis and others | ||
+ | * Fatality rates of outcomes | ||
+ | * Incidence rates of outcomes by specific blood products transfused: red blood cells, plasma, platelets, full blood | ||
+ | * Incidence rates of outcomes by blood component processing: leukocyte reduction, irradiation, pathogen-reduction | ||
+ | * Incidence rates of outcomes by indication and associated procedures and other possible risk factors | ||
+ | * Incidence rates of outcomes by donor characteristics | ||
+ | |||
+ | == Modelling Issues == | ||
+ | |||
+ | * Detailed facts about transfused units, such as | ||
+ | * Manipulation: cultured enrichment, demineralization, genetical modification, | ||
+ | * Concentration, dosage, portioning and unit of issue, | ||
+ | * Preservation: irradiation and pathogen reduction, transport, storage, cryoprotection, | ||
+ | * monitoring: preparation, processing, mobilization, modification, quarantine, | ||
+ | * Additive, excipient and nutrient content | ||
- | * Modelling Isues: | ||
- | * Detailed facts about transfused units, such as | ||
* [[projects:workgroups:transfusion:members|Participants]] | * [[projects:workgroups:transfusion:members|Participants]] |