Date(s) - 05/02/2018 - 05/03/2018
Columbia University Medical Center
Categories No Categories
What happens when collaborators from across the OHDSI community come together?
We run a study!
Here’s what’s going to happen:
Over the next three months community members are invited to post clinical research questions on the OHDSI forum. Then, at the face-to-face, those in attendance will select one clinical question to focus on over the 2-days. The selected question will be based on community feedback and data availability.
Then, the real fun will start! Once aligned on a common problem, we will break out into groups to tackle the specific components required to design and implement the study:
- Group #1 will focus on defining the target and comparator cohorts, ensuring that we have an adequate capture of the exposures of interest and proper application of whatever inclusion criteria are necessary to define the appropriate study population.
- Group #2 will create and validate an outcome cohort definition.
- Group #3 will produce a list of negative control outcomes that will be used for empirical calibration.
- Group #4 will make the analytic design choices and prepare an R package that implements the study using the CohortMethod package.
These activities will all be pulled together into an open community protocol and that initial draft will need to be completed on day one. Once the draft protocol is finished, everyone will have free time to explore New York and network on their own.
On day two, we will get the study package running across the OHDSI network. Data holders (with a CDMv5) will be able to kick off the study in the morning with the aim of having results to share with the community in the afternoon. While the study is running, we will hold a community brainstorm to discuss what we as a community can do to improve the validity and efficiency of observational research. From there, we will review the study diagnostics from all the participating data partners, and with any luck, have a final protocol and study results to share with the world!
Not sure if you should attend? If one of the following statements applies to you, we’d encourage you to register:
- You are passionate about the clinical questions that are to be studied, and can contribute to the clinical understanding of the problem and the synthesis of the evidence we generate with what is already known.
- You want to contribute to the epidemiological design of a clinical study, and see yourself leading the definition of exposure/outcome cohorts based on your clinical understanding and knowledge of observational databases.
- You want to apply your statistical expertise to the design of a population-level effect estimation study, and plan to contribute to the implementation of a R package that parameterizes the CohortMethod and associated OHDSI tools into an end-to-end study.
- You have observational data in the OMOP Common Data Model v5 format, and want to execute a network study against your data and share aggregate summary results with the community to advance our collective evidence about the question of interest.
|8:00 – 9:00am||Registration||9:00 – 10:00am||Overview of Research Question: To determine the comparative risk developing malignancy in patients with moderate to severe rheumatoid arthritis treated with tofacitinib and tumor necrosis factor inhibitors (TNFi)|
|10:00 – 1:00pm||Breakout sessions
*Coffee will be available during this time
|1:00 – 2:00pm||Group working lunch, with progress update from breakouts|
|2:00 – 4:30pm||Continue in breakout groups|
|4:30 – 5:30pm||Reconvene: Each group will present their work from the day|
|5:30pm Onward||Complete unfinished work, dinner on your own|
|8:00 – 9:30am||Data holders to start running the study package on their data to generate the study diagnostics.|
|9:00 – 10:30am||Review study diagnostics from initial databases presented while code is run on other datasets|
|11:00 – 12:30pm||Group Brainstorm: Given the current study process, how can we improve research and facilitate more network research studies?|
|12:30 – 1:30pm||Lunch|
|1:30 – 3:00pm||Review diagnostics results from all participating data partners|
|3:00 – 3:30pm||Break|
|3:30 – 4:30pm||Review results and discuss next steps for evidence generation and dissemination for this community study|
|4:30 – 5:30pm||Group Brainstorm: What else should OHDSI do together to advance our shared mission?|
The 2018 F2F will take place at the Department of Biomedical Informatics located at:
Department of Biomedical Informatics
Columbia University Medical Center
622 W. 168th Street, Presbyterian Building 20th Floor
New York, NY 10032
Travel directions to the the department are available here:
2296 Frederick Douglass Blvd, New York, NY 10027
514 W 168th St, New York, NY 10032
The Excelsior Hotel
45 West 81ST Street, New York, NY 10024
2130 Broadway, New York, NY 10023
250 W 77th St, New York, NY 10024
2528 Broadway, New York, NY 10025
358 W 58th St, New York, NY 10019
Courtyard by Marriott New York Manhattan/Central Park
1717 Broadway, New York, NY 10019
NYLO New York City
2178 Broadway, New York, NY 10024
The Empire Hotel
44 W 63rd St, New York, NY 10023
The Lucerne Hotel
201 W 79th St, New York, NY 10024
Selected participants will be notified on March 23rd.
This is a working meeting. All in attendance are expected to participate in discussions and contribute their knowledge and skills to each session they attend.